Key laboratory for biosensors of Shandong province was built in 1999, which has mainly worked on research and development of biological sensors and instruments, study on new on-line detected and automatic controlled biological reactor, and biosensor technology extension services. Over the years, based on the studies of older scientific experts in biology institute, we continue to innovate and developed independently dozens of new biological testing instruments with three of them as national new products, breaking the overseas technical monopoly. In the field of biosensors analysis technology, we have developed the biosensors which only realized industrial application in our country.